Isolated clubfoot among newborns, finds CMCH and attribute two new mutated chromosomes to be the cause of it
Coimbatore: Institute of Orthopedics and Traumatology in Coimbatore Medical College Hospital (CMCH) finds out isolated clubfoot, a condition in which the foot is twisted out of shape, among newborns and attribute two new mutated chromosomes to be the cause of it.
This clubfoot is characterized by structural changes of several tissues of the foot and lower leg, which left untreated end up in difficulty in leading a normal life and make the child dependent on others for carrying out their daily activities.
They have difficulty in squatting which is a common position used for daily activities like toileting and farming. The cause of the clubfoot, possibly the two new mutated chromosomes, are said to be the chromosomes5: 135031277and chromosome5:135031344, in the study conducted by the department’s director and postgraduate student.
The study by Vetrivel Chezhian, director of the department and Salmon khan, postgraduate student revealed that two new mutated chromosomes are the cause besides the fact it is due to hereditary and abnormal positioning of the embryo in the uterus. It is said in the journal that as many as 32 male and 18 female children have been included in the study conducted by them during December 2019 to June 2020.
At least 23 babies had bilateral clubfoot, while 18 had right-sided and 9 had a left-sided clubfoot, revealed the study. The study also revealed that the mutated chromosome5: 135031277was associated with isolated non-syndromic clubfootbabies, which according to the results, is 2.26 times more likely to happen than the already reported chromosome5: 135031290 mutation group.
Also, approximately 25% of all isolated cases report a familial history of clubfoot. Data from studies on twin babies show a higher concordance in monozygotic (33%) than dizygotic (3%) twins and more recent data estimates heritability of isolated clubfoot at around 30%. The authors noted that they hope this study will encourage future studies and aid in improving the genetic knowledge of club foot in India.
This clubfoot is characterized by structural changes of several tissues of the foot and lower leg, which left untreated end up in difficulty in leading a normal life and make the child dependent on others for carrying out their daily activities.
They have difficulty in squatting which is a common position used for daily activities like toileting and farming. The cause of the clubfoot, possibly the two new mutated chromosomes, are said to be the chromosomes5: 135031277and chromosome5:135031344, in the study conducted by the department’s director and postgraduate student.
The study by Vetrivel Chezhian, director of the department and Salmon khan, postgraduate student revealed that two new mutated chromosomes are the cause besides the fact it is due to hereditary and abnormal positioning of the embryo in the uterus. It is said in the journal that as many as 32 male and 18 female children have been included in the study conducted by them during December 2019 to June 2020.
At least 23 babies had bilateral clubfoot, while 18 had right-sided and 9 had a left-sided clubfoot, revealed the study. The study also revealed that the mutated chromosome5: 135031277was associated with isolated non-syndromic clubfootbabies, which according to the results, is 2.26 times more likely to happen than the already reported chromosome5: 135031290 mutation group.
Also, approximately 25% of all isolated cases report a familial history of clubfoot. Data from studies on twin babies show a higher concordance in monozygotic (33%) than dizygotic (3%) twins and more recent data estimates heritability of isolated clubfoot at around 30%. The authors noted that they hope this study will encourage future studies and aid in improving the genetic knowledge of club foot in India.