Deadly Meningitis Appears to Be Cleared With Antipsychotics in Early Trials

A new study on mice suggests that some antipsychotic drugs could also help us tackle the most common form of meningitis.

A new study on mice suggests that some antipsychotic drugs could also help us tackle the most common form of meningitis. 

Bacterial meningitis (Neisseria meningitidis) is a serious infection that causes dangerous swelling in the tissue around the brain and spinal cord.

Each year, over 30,000 cases are reported. While most patients recover with antibiotics, if the disease is left untreated, it can cause severe brain damage and even death, sometimes within just a few hours.

But a team of scientists from the Institut Cochin in Paris think they've found a better way to treat this disease. Using mouse models, their research shows that a class of antipsychotics, called phenothiazines can stop meningitis from sticking - quite literally.

The drugs are said to work within minutes, disabling the bacterium's long, sticky arms, called Type IV pili. Without these crucial appendages, the bacterium can no longer move, clump together, or cling to blood vessels as easily.

"These compounds exert a strong protective effect," the authors write.

"They reduce meningococcal colonisation of the human vessels and prevent subsequent vascular dysfunctions, intravascular coagulation and overwhelming inflammation, the hallmarks of invasive meningococcal infections. Finally, they reduce lethality."

The medicine works by disarming but not exactly killing the infection; that's where antibiotics can still play a role. When standard antibiotics are used in conjunction with these antipsychotics, the authors say that their efficiency only grows stronger.

As such, it's hoped that together, the two treatments could disrupt existing clumps of the bacterium in humans (which antibiotics cannot currently do) and let the antibiotics kill the infection at play.

Obviously, clinical trials will be needed before we verify whether these drugs can be including in an effective treatment for meningitis, but the authors are hopeful given the drug can already be used in humans.

"It is therapeutically safe with few side effects when used in moderation, as proven by the 60 plus years it has been in use," they write.

"We showed that it reduced vascular lesions and improved mouse survival in the absence of antibiotic treatment when administered early during the infection."

Newsletter

Rathinam Physiotherapy Clinic inaugurated

Rathinam College of Physiotherapy (RCP), a part of Rathinam Group of Institutions inaugurated Rathinam Physiotherapy Cli...

National Doctors Day - Celebrations at Coimbatore Government Hospital

At the Government Medical College Hospital in Coimbatore, a cake was cut and celebrated on the occasion of National Doct...

Rotary Smartcity and Sri Ramakrishna Hospital launch Project Miracle!

On Monday, 26th of June, the Rotary Club of Coimbatore Smartcity initiated a Rotary International Global Grant Project c...

Health Department announces intensive diarrhoea prevention camp

Deputy director of health Department Aruna has announced that an intensive diarrhoea prevention camp will be held in Coi...

Special medical camp in Thondamuthur town panchayat

In Thondamuthur Town Panchayat, a special medical camp for sanitation workers and general public was held at the Town Pa...

Covid-19: 12,000 pregnant women under observation in Coimbatore

As many as 12,000 pregnant women are being monitored by village nurses in Coimbatore district, health department officia...